Nucleobase Protection of Deoxyribo‐ and Ribonucleosides
نویسندگان
چکیده
منابع مشابه
Cytostatic and Antiviral 6-Arylpurine Ribonucleosides IX. Synthesis and Evaluation of 6-Substituted 3-Deazapurine Ribonucleosides
A series of 3-deazapurine ribonucleosides 5a–5l bearing diverse C-substituents (alkyl, aryl and heteroaryl) in the position 6 were prepared by Pd-catalyzed cross-coupling reactions of either free 6-chloro-3-deazapurine ribonucleoside 4 or its acetyl protected congener 3 followed by deprotection. An improved synthesis of the starting 4-chloro-1-(2,3,5-tri-O-acetylβ-D-ribofuranosyl)-1H-imidazo[4,...
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Wehave recently found that 2,5,6-trichloroH~-D-ribofuranosyl)benzimidazole(TCRB) and the corresponding 2-bromo analog have better in vitro activities against HCMV than the clinically used agents ganciclovir and foscarnet, These benzimidazole nucleosides act by a unique mechanism, however, their biological target has not been completely identified. As an approach to probing the target, we have d...
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In 1962, Aposhian and Kornberg' described a procedure for partial purification of the DNA polymerase induced by infection of Escherichia coli with bacteriophage T2. They observed that their purest preparation of phage-induced DNA polymerase exhibited deoxyribonuclease activity when assayed with heat-denatured DNA as substrate. Recently, Lucas and Kornberg2,3 purified the DNA polymerase induced ...
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Disaccharide nucleosides are an important class of natural compounds that have a variety of biological activities. In this study, we report on the synthesis of disaccharide nucleosides utilizing the temporary protection of the 2',3'-cis-diol of ribonucleosides, such as adenosine, guanosine, uridine, 5-metyluridine, 5-fluorouridine and cytidine, by a boronic ester. The temporary protection of th...
متن کاملThe ultraviolet absorption spectra of the pyrimidine ribonucleosides and ribonucleotides.
It is well known that the high and characteristic absorption of nucleic acids in ultraviolet light is due to the absorption of their purine and pyrimidine components. Several workers have measured the absorption curves of the aminoand oxypurines (l-3) and Jordan has obtained similar data for adenosine and guanosine and for the corresponding nucleotides (3). In the latter instances substitution ...
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ژورنال
عنوان ژورنال: Current Protocols in Nucleic Acid Chemistry
سال: 2017
ISSN: 1934-9270,1934-9289
DOI: 10.1002/cpnc.32